Factor Xa Active Site Substrate Specificity with Substrate Phage Display and Computational Molecular Modeling
نویسندگان
چکیده
منابع مشابه
Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling.
Structural origin of substrate-enzyme recognition remains incompletely understood. In the model enzyme system of serine protease, canonical anti-parallel beta-structure substrate-enzyme complex is the predominant hypothesis for the substrate-enzyme interaction at the atomic level. We used factor Xa (fXa), a key serine protease of the coagulation system, as a model enzyme to test the canonical c...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.m708843200